Production of an attenuated influenza A (H3N2) strain "KO-1" by recombination with A/Okuda/57 (H2N2) followed by selection of inhibitor-resistant virus.
Identifieur interne : 002773 ( Main/Exploration ); précédent : 002772; suivant : 002774Production of an attenuated influenza A (H3N2) strain "KO-1" by recombination with A/Okuda/57 (H2N2) followed by selection of inhibitor-resistant virus.
Auteurs : A. Yamada ; Y. Okuno ; M. Takahashi ; K. NakajimaSource :
- Biken journal [ 0006-2324 ] ; 1980.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (biosynthèse), Antiviraux (pharmacologie), Cricetinae, Enfant d'âge préscolaire, Gènes viraux, Humains, Poumon (microbiologie), Recombinaison génétique, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Vaccins antigrippaux (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité).
- MESH :
- biosynthèse : Anticorps antiviraux.
- génétique : Virus de la grippe A.
- immunologie : Vaccins antigrippaux, Virus de la grippe A.
- microbiologie : Poumon.
- pathogénicité : Virus de la grippe A.
- pharmacologie : Antiviraux.
- Animaux, Cricetinae, Enfant d'âge préscolaire, Gènes viraux, Humains, Recombinaison génétique, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (biosynthesis), Antiviral Agents (pharmacology), Child, Preschool, Cricetinae, Genes, Viral, Humans, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (pathogenicity), Influenza Vaccines (immunology), Lung (microbiology), Recombination, Genetic.
- MESH :
- chemical , biosynthesis : Antibodies, Viral.
- chemical , immunology : Influenza Vaccines.
- chemical , pharmacology : Antiviral Agents.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- microbiology : Lung.
- pathogenicity : Influenza A virus.
- Animals, Child, Preschool, Cricetinae, Genes, Viral, Humans, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Recombination, Genetic.
Abstract
A live attenuated influenza A (H3N2) strain "KO-1" was developed by recombination of wild influenza A/Kumamoto/22/76 (H3N2) with attenuated A/Okuda/57 (H2N2) followed by passage in developing chick eggs in the presence of horse serum inhibitor. The virus strain "KO-1" obtained is inhibitor-resistant, and has hemagglutinating (HA) and neuraminidase (NA) antigenicity derived from the wild parent virus. RNA analysis revealed that one RNA segment (corresponding to M protein) was derived from the A/Okuda/57 strain. The "KO-1" strain shows restricted growth in the lungs of Syrian hamsters as compared with that of the parent A/Kumamoto/76 strain and no transmission of virus from the hamsters infected with "KO-1" strain by inhalation ot untreated hamsters housed in the same cage was detected serologically. In contrast, the parent wild A/Kumamoto/76 strain induced contact infection under the same condition. The attenuated "KO-1" strain was administered by inhalation to a few children of 3 to 4 years old in a preliminary clinical trial. A good antibody response was observed with no clinical reaction.
PubMed: 7437002
Affiliations:
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Le document en format XML
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Yamada</name></author><author><name sortKey="Okuno, Y" sort="Okuno, Y" uniqKey="Okuno Y" first="Y" last="Okuno">Y. Okuno</name></author><author><name sortKey="Takahashi, M" sort="Takahashi, M" uniqKey="Takahashi M" first="M" last="Takahashi">M. Takahashi</name></author><author><name sortKey="Nakajima, K" sort="Nakajima, K" uniqKey="Nakajima K" first="K" last="Nakajima">K. Nakajima</name></author></analytic><series><title level="j">Biken journal</title><idno type="ISSN">0006-2324</idno><imprint><date when="1980" type="published">1980</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (biosynthesis)</term><term>Antiviral Agents (pharmacology)</term><term>Child, Preschool</term><term>Cricetinae</term><term>Genes, Viral</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza Vaccines (immunology)</term><term>Lung (microbiology)</term><term>Recombination, Genetic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (biosynthèse)</term><term>Antiviraux (pharmacologie)</term><term>Cricetinae</term><term>Enfant d'âge préscolaire</term><term>Gènes viraux</term><term>Humains</term><term>Poumon (microbiologie)</term><term>Recombinaison génétique</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Child, Preschool</term><term>Cricetinae</term><term>Genes, Viral</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Recombination, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cricetinae</term><term>Enfant d'âge préscolaire</term><term>Gènes viraux</term><term>Humains</term><term>Recombinaison génétique</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A live attenuated influenza A (H3N2) strain "KO-1" was developed by recombination of wild influenza A/Kumamoto/22/76 (H3N2) with attenuated A/Okuda/57 (H2N2) followed by passage in developing chick eggs in the presence of horse serum inhibitor. The virus strain "KO-1" obtained is inhibitor-resistant, and has hemagglutinating (HA) and neuraminidase (NA) antigenicity derived from the wild parent virus. RNA analysis revealed that one RNA segment (corresponding to M protein) was derived from the A/Okuda/57 strain. The "KO-1" strain shows restricted growth in the lungs of Syrian hamsters as compared with that of the parent A/Kumamoto/76 strain and no transmission of virus from the hamsters infected with "KO-1" strain by inhalation ot untreated hamsters housed in the same cage was detected serologically. In contrast, the parent wild A/Kumamoto/76 strain induced contact infection under the same condition. The attenuated "KO-1" strain was administered by inhalation to a few children of 3 to 4 years old in a preliminary clinical trial. A good antibody response was observed with no clinical reaction.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Nakajima, K" sort="Nakajima, K" uniqKey="Nakajima K" first="K" last="Nakajima">K. Nakajima</name><name sortKey="Okuno, Y" sort="Okuno, Y" uniqKey="Okuno Y" first="Y" last="Okuno">Y. Okuno</name><name sortKey="Takahashi, M" sort="Takahashi, M" uniqKey="Takahashi M" first="M" last="Takahashi">M. Takahashi</name><name sortKey="Yamada, A" sort="Yamada, A" uniqKey="Yamada A" first="A" last="Yamada">A. Yamada</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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